Primary Identifier | MGI:2445724 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Rarg |
Transmission | Germline | Strain of Origin | 129/Sv |
Is Recombinase | false | Is Wild Type | false |
molecularNote | An isoform specific disruption was achieved by the insertion of a promoterless neomycin selection cassette into exon 3 via homologous recombination. Whereas gamma1 transcript was undetected by RT-PCR analysis of homozygous mutant mice, gamma2 mRNA was readily amplified. An RNAse protection assay further indicated the absence of the gamma1 isoform. |