| Primary Identifier | MGI:2445786 | Allele Type | Transgenic |
| Attribute String | Transactivator | Gene | Tg(Prnp-tTA)F959Sbp |
| Strain of Origin | FVB.129S7(B6)-Prnp<tm1Cwe>/J | Is Recombinase | false |
| Is Wild Type | false |
| description | This transgene was originally microinjected into Prnptm1Cwe oocytes. Founder F973 exhibits the highest level of transgene expression, followed by founders F959 and F966. |
| molecularNote | A tet transactivator gene under the control of a mouse Prnp promoter was used for the transgene. The mouse Prnp promoter targets transgene expression to the brain. High levels of transgene expression was observed in the cortex and hippocampus, and lower levels were observed in thalamic, hypothalamic, and brainstem regions via mRNA in situ hybridization. |
