First Author | Bao-Cutrona M | Year | 2009 |
Journal | Genetics | Volume | 181 |
Issue | 4 | Pages | 1687-91 |
PubMed ID | 19204377 | Mgi Jnum | J:147292 |
Mgi Id | MGI:3840032 | Doi | 10.1534/genetics.108.097600 |
Citation | Bao-Cutrona M, et al. (2009) Unexpected expression pattern of tetracycline-regulated transgenes in mice. Genetics 181(4):1687-91 |
abstractText | In generating a conditional transgenic murine model based on a tetracycline-regulated system, we obtained unexpected patterns of expression due to the transcriptional inactivity of the tet-responder promoter. Here we show strong cell-type-restricted expression that was variegated to an extent determined by the number of responder transgene copies integrated into the host genome. |