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Publication : Unexpected expression pattern of tetracycline-regulated transgenes in mice.

First Author  Bao-Cutrona M Year  2009
Journal  Genetics Volume  181
Issue  4 Pages  1687-91
PubMed ID  19204377 Mgi Jnum  J:147292
Mgi Id  MGI:3840032 Doi  10.1534/genetics.108.097600
Citation  Bao-Cutrona M, et al. (2009) Unexpected expression pattern of tetracycline-regulated transgenes in mice. Genetics 181(4):1687-91
abstractText  In generating a conditional transgenic murine model based on a tetracycline-regulated system, we obtained unexpected patterns of expression due to the transcriptional inactivity of the tet-responder promoter. Here we show strong cell-type-restricted expression that was variegated to an extent determined by the number of responder transgene copies integrated into the host genome.
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