| Primary Identifier | MGI:2445938 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Fbn2 |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region contained the 5' untranslated region and sequence encoding the signal peptide and the first 85 residues of the protein. Northern blot analysis of mRNA obtained from newborn lung tissue indicated an absence of transcript in homozygous mutant mice. No protein was detected by Western blot analysis of conditioned media obtained from homozygous mutant fibroblast cultures. |
