| Primary Identifier | MGI:2445832 | Allele Type | Transgenic |
| Attribute String | Recombinase | Gene | Tg(KRT14-cre)1Amc |
| Strain of Origin | (C57BL/6 x CBA)F1 | Is Recombinase | true |
| Is Wild Type | false |
| description | This allele is representative of 2 founders (#199 and #200) exhibiting the highest level of transgene expression. Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. |
| molecularNote | The transgene is composed of a cre recombinase gene under the control of a human keratin 14 promoter. The human KRT14 promoter directs transgene expression in hair and skin. The transgene also contains a human growth hormone sequence and polyadenylation signal. When crossed to a transgenic reporter line, beta-galactosidase activity was detected in the oral ectoderm at 11.75 dpc, and at 14.5 dpc activity is detected in the skin and throughout the dental epithelium. |
