Other
12 Authors
- Gordon W,
- Andersen B,
- Nie Q,
- Kashgari G,
- Plikus MV,
- Ruiz B,
- Yang J,
- Xie Y,
- Ho H,
- Jester JV,
- Ma AL,
- Meinecke L
| First Author | Kashgari G | Year | 2020 |
| Journal | Dev Cell | Volume | 52 |
| Issue | 6 | Pages | 764-778.e4 |
| PubMed ID | 32109382 | Mgi Jnum | J:286600 |
| Mgi Id | MGI:6402858 | Doi | 10.1016/j.devcel.2020.01.032 |
| Citation | Kashgari G, et al. (2020) Epithelial Migration and Non-adhesive Periderm Are Required for Digit Separation during Mammalian Development. Dev Cell 52(6):764-778.e4 |
| abstractText | The fusion of digits or toes, syndactyly, can be part of complex syndromes, including van der Woude syndrome. A subset of van der Woude cases is caused by dominant-negative mutations in the epithelial transcription factor Grainyhead like-3 (GRHL3), and Grhl3(-/-)mice have soft-tissue syndactyly. Although impaired interdigital cell death of mesenchymal cells causes syndactyly in multiple genetic mutants, Grhl3(-/-) embryos had normal interdigital cell death, suggesting alternative mechanisms for syndactyly. We found that in digit separation, the overlying epidermis forms a migrating interdigital epithelial tongue (IET) when the epithelium invaginates to separate the digits. Normally, the non-adhesive surface periderm allows the IET to bifurcate as the digits separate. In contrast, in Grhl3(-/-) embryos, the IET moves normally between the digits but fails to bifurcate because of abnormal adhesion of the periderm. Our study identifies epidermal developmental processes required for digit separation. |
