| First Author | Su Q | Year | 2019 |
| Journal | J Invest Dermatol | Volume | 139 |
| Issue | 11 | Pages | 2313-2323.e8 |
| PubMed ID | 31129057 | Mgi Jnum | J:284604 |
| Mgi Id | MGI:6387330 | Doi | 10.1016/j.jid.2019.05.006 |
| Citation | Su Q, et al. (2019) Keratinocytes Share Gene Expression Fingerprint with Epidermal Langerhans Cells via mRNA Transfer. J Invest Dermatol 139(11):2313-2323.e8 |
| abstractText | The immune functions of epithelia-resident dendritic cells are influenced by epithelial-derived cytokines. Here we identified a communication form between tissue-resident dendritic cells and niche cells that allows direct intracellular material exchange between the parties. We show that many keratinocyte (KC)-specific molecules such as keratins and adhesion molecules could be detected in the epidermal-resident Langerhans cells (LCs) as mRNA and protein. Furthermore, KC-derived Cre led to genetic recombination in the LCs. We also found that LCs containing KC-derived material were more prone to migration. The KC-specific signatures were transferred from KCs to LCs through an exosome-independent mechanism that likely involved nanotubes/dendrites. The transfer of material between epithelial cells and epithelia-associated dendritic cells was not limited to mice or to KC-to-LC transfer. Taken together, these data suggest that the epithelial environment might have a long-term effect on dendritic cell biology and that genetic tools that specifically target epithelial cells also affect tissue-resident immune cells. |
