| First Author | Panneton V | Year | 2018 |
| Journal | J Immunol | Volume | 200 |
| Issue | 9 | Pages | 3067-3076 |
| PubMed ID | 29581356 | Mgi Jnum | J:261486 |
| Mgi Id | MGI:6155350 | Doi | 10.4049/jimmunol.1701305 |
| Citation | Panneton V, et al. (2018) ICOS Signaling Controls Induction and Maintenance of Collagen-Induced Arthritis. J Immunol 200(9):3067-3076 |
| abstractText | ICOS is a key costimulatory receptor facilitating differentiation and function of follicular helper T cells and inflammatory T cells. Rheumatoid arthritis patients were shown to have elevated levels of ICOS(+) T cells in the synovial fluid, suggesting a potential role of ICOS-mediated T cell costimulation in autoimmune joint inflammation. In this study, using ICOS knockout and knockin mouse models, we found that ICOS signaling is required for the induction and maintenance of collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis. For the initiation of CIA, the Tyr(181)-based SH2-binding motif of ICOS that is known to activate PI3K was critical for Ab production and expansion of inflammatory T cells. Furthermore, we found that Tyr(181)-dependent ICOS signaling is important for maintenance of CIA in an Ab-independent manner. Importantly, we found that a small molecule inhibitor of glycolysis, 3-bromopyruvate, ameliorates established CIA, suggesting an overlap between ICOS signaling, PI3K signaling, and glucose metabolism. Thus, we identified ICOS as a key costimulatory pathway that controls induction and maintenance of CIA and provide evidence that T cell glycolytic pathways can be potential therapeutic targets for rheumatoid arthritis. |
