| Primary Identifier | MGI:2445949 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(LPV-TAg121)2Tvd |
| Strain of Origin | (C57BL/6J x DBA/2J)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | All transgenic mice examined at ~26 weeks of age had choroid plexus tumors. These tumors grew more slowly than similar tumors seen in transgenic mice carrying the wild-type T antigen (Tg(LPV-Tag)1Tvd). |
| molecularNote | The transgene consists of a lymphotrophic papovavirus (LPV) enhancer/early promoter and a mutant SV40 T antigen sequence truncated after amino acid 121 followed by 11 missense residues. The resulting protein includes the RB1-binding region but lacks the small t antigen and TRP53-binding region. Regulatory sequences direct expression of the transgene in B- and T-lymphocytes and choroid plexus epithelium. |
