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Allele : Ltb/Tnf/Lta<tm1Dvk> tumor necrosis factor; targeted mutation 1, Dmitry V Kuprash

Primary Identifier  MGI:2446567 Allele Type  Targeted
Attribute String  Null/knockout Gene  Tnf
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  An 8.4 kb region, containing the entire Tnf gene and the last coding exons of the Lta and Ltb genes, was deleted by cre mediated recombination of surrounding loxP sites inserted within Lta and Ltb via homologous recombination. Partial coding regions of Lta and Ltb were left intact separated by a single loxP site, however RT-PCR analysis of homozygous mutant splenocytes activated by concanavalin A indicated an absence of transcript from each locus.
  • mutations:
  • Intergenic deletion
  • synonyms:
  • TNF/LTDelta3,
  • Tnfabc<->,
  • Tnfabc<->,
  • TNF/LTDelta3
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

12 Publication categories