| First Author | Kwon H | Year | 2014 |
| Journal | Cell Rep | Volume | 9 |
| Issue | 5 | Pages | 1574-83 |
| PubMed ID | 25466256 | Mgi Jnum | J:222186 |
| Mgi Id | MGI:5644103 | Doi | 10.1016/j.celrep.2014.10.068 |
| Citation | Kwon H, et al. (2014) Adipocyte-specific IKKbeta signaling suppresses adipose tissue inflammation through an IL-13-dependent paracrine feedback pathway. Cell Rep 9(5):1574-83 |
| abstractText | Adipose tissue inflammation is one pathway shown to mediate insulin resistance in obese humans and rodents. Obesity induces dynamic cellular changes in adipose tissue to increase proinflammatory cytokines and diminish anti-inflammatory cytokines. However, we have found that anti-inflammatory interleukin-13 (IL-13) is unexpectedly induced in adipose tissue of obese humans and high-fat diet (HFD)-fed mice, and the source of IL-13 is primarily the adipocyte. Moreover, HFD-induced proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) and IL-1beta mediate IL-13 production in adipocytes in an IKKbeta-dependent manner. In contrast, adipocyte-specific IKKbeta-deficient mice show diminished IL-13 expression and enhanced inflammation after HFD feeding, resulting in a worsening of the insulin-resistant state. Together these data demonstrate that although IKKbeta activates the expression of proinflammatory mediators, in adipocytes, IKKbeta signaling also induces the expression of the anti-inflammatory cytokine IL-13, which plays a unique protective role by limiting adipose tissue inflammation and insulin resistance. |
