| First Author | Boone CW | Year | 1998 |
| Journal | Mutat Res | Volume | 402 |
| Issue | 1-2 | Pages | 173-7 |
| PubMed ID | 9675271 | Mgi Jnum | J:52613 |
| Mgi Id | MGI:1329864 | Doi | 10.1016/s0027-5107(97)00295-9 |
| Citation | Boone CW, et al. (1998) Use of Druckrey analysis to quantitatively evaluate the chemopreventive efficacy of N-difluoromethylornithine (DFMO), a prototype proliferation inhibitor. Mutat Res 402(1-2):173-7 |
| abstractText | Druckrey analysis of the results of skin painting TG.AC transgenic mice with three different doses of benzo[a]pyrene was used to obtain quantitative estimates of the in vivo cancer chemo-preventive efficacy of N-difluoromethylornithine. The percent decrease in mean rate of subvisible tumor development during the tumor latent period produced by 2000 ppm and 4000 ppm DFMO in the diet was 39% and 50%, respectively. Druckrey analysis was also successfully applied to transformations of published data on human cigarette smokers. The time before onset of lung cancer in 2% of smokers was prolonged 17 weeks for every cigarette per day not smoked. The Druckrey model, of substantiated validity because of the results in human smokers, provides a rapid quantitative screening method applicable to large numbers of candidate chemopreventive agents. Copyright 1998 Elsevier Science B.V. All rights reserved. |
