| First Author | Sato M | Year | 2000 |
| Journal | Immunity | Volume | 13 |
| Issue | 4 | Pages | 539-48 |
| PubMed ID | 11070172 | Mgi Jnum | J:98127 |
| Mgi Id | MGI:3577475 | Doi | 10.1016/s1074-7613(00)00053-4 |
| Citation | Sato M, et al. (2000) Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity 13(4):539-48 |
| abstractText | Induction of the interferon (IFN)-alpha/beta gene transcription in virus-infected cells is an event central to innate immunity. Mice lacking the transcription factor IRF-3 are more vulnerable to virus infection. In embryonic fibroblasts, virus-induced IFN-alpha/beta gene expression levels are reduced and the spectrum of the IFN-alpha mRNA subspecies altered. Furthermore, cells additionally defective in IRF-7 expression totally fail to induce these genes in response to infections by any of the virus types tested. In these cells, a normal profile of IFN-alpha/beta mRNA induction can be achieved by coexpressing both IRF-3 and IRF-7. These results demonstrate the essential and distinct roles of thetwo factors, which together ensure the transcriptional efficiency and diversity of IFN-alpha/beta genes for the antiviral response. |
