| First Author | Hayashi K | Year | 2015 |
| Journal | Oncogene | Volume | 34 |
| Issue | 35 | Pages | 4647-55 |
| PubMed ID | 25486434 | Mgi Jnum | J:231809 |
| Mgi Id | MGI:5775144 | Doi | 10.1038/onc.2014.398 |
| Citation | Hayashi K, et al. (2015) Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA. Oncogene 34(35):4647-55 |
| abstractText | Somatic mutations in the gene encoding the catalytic subunit of protein phosphatase 6 (Ppp6c) have been identified in malignant melanoma and are thought to function as a driver in B-raf- or N-ras-driven tumorigenesis. To assess the role of Ppp6c in carcinogenesis, we generated skin keratinocyte-specific Ppp6c conditional knockout mice and performed two-stage skin carcinogenesis analysis. Ppp6c deficiency induced papilloma formation with 7,12-dimethylbenz (a) anthracene (DMBA) only, and development of those papillomas was significantly accelerated compared with that seen following DMBA/TPA (12-O-tetradecanoylphorbol 13-acetate) treatment of wild-type mice. NF-kappaB activation either by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta was enhanced in Ppp6c-deficient keratinocytes. Overall, we conclude that Ppp6c deficiency predisposes mice to skin carcinogenesis initiated by DMBA. This is the first report showing that such deficiency promotes tumor formation in mice. |
