| First Author | Mesa KR | Year | 2018 |
| Journal | Cell Stem Cell | Volume | 23 |
| Issue | 5 | Pages | 677-686.e4 |
| PubMed ID | 30269903 | Mgi Jnum | J:271533 |
| Mgi Id | MGI:6278087 | Doi | 10.1016/j.stem.2018.09.005 |
| Citation | Mesa KR, et al. (2018) Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation. Cell Stem Cell 23(5):677-686.e4 |
| abstractText | Maintenance of adult tissues depends on sustained activity of resident stem cell populations, but the mechanisms that regulate stem cell self-renewal during homeostasis remain largely unknown. Using an imaging and tracking approach that captures all epidermal stem cell activity in large regions of living mice, we show that self-renewal is locally coordinated with epidermal differentiation, with a lag time of 1 to 2 days. In both homeostasis and upon experimental perturbation, we find that differentiation of a single stem cell is followed by division of a direct neighbor, but not vice versa. Finally, we show that exit from the stem cell compartment is sufficient to drive neighboring stem cell self-renewal. Together, these findings establish that epidermal stem cell self-renewal is not the constitutive driver of homeostasis. Instead, it is precisely tuned to tissue demand and responds directly to neighbor cell differentiation. |
