| First Author | Hayashi Y | Year | 2015 |
| Journal | Science | Volume | 350 |
| Issue | 6263 | Pages | 957-61 |
| PubMed ID | 26494173 | Mgi Jnum | J:227055 |
| Mgi Id | MGI:5699623 | Doi | 10.1126/science.aad1023 |
| Citation | Hayashi Y, et al. (2015) Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice. Science 350(6263):957-61 |
| abstractText | Mammalian sleep comprises rapid eye movement (REM) sleep and non-REM (NREM) sleep. To functionally isolate from the complex mixture of neurons populating the brainstem pons those involved in switching between REM and NREM sleep, we chemogenetically manipulated neurons of a specific embryonic cell lineage in mice. We identified excitatory glutamatergic neurons that inhibit REM sleep and promote NREM sleep. These neurons shared a common developmental origin with neurons promoting wakefulness; both derived from a pool of proneural hindbrain cells expressing Atoh1 at embryonic day 10.5. We also identified inhibitory gamma-aminobutyric acid-releasing neurons that act downstream to inhibit REM sleep. Artificial reduction or prolongation of REM sleep in turn affected slow-wave activity during subsequent NREM sleep, implicating REM sleep in the regulation of NREM sleep. |
