| Primary Identifier | MGI:2446467 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Trrap |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | No mice derived from ES cells bearing the "floxed" allele from which only the neo-tk cassette had been deleted were recovered. |
| molecularNote | The exon encoding the beginning of the protein's kinase-like domain was flanked upstream by a single loxP site and downstream by a loxP-flanked neomycin resistance-thymidine kinase (neor-tk) cassette inserted into the intron corresponding to intron 64 of the orthologous human gene. The absence of homozygous progeny from crosses of mice heterozygous for this allele demonstrates functional disruption of the gene or protein. |
