| First Author | Grass S | Year | 2003 |
| Journal | Neurosci Lett | Volume | 345 |
| Issue | 3 | Pages | 153-6 |
| PubMed ID | 12842279 | Mgi Jnum | J:107608 |
| Mgi Id | MGI:3621532 | Doi | 10.1016/s0304-3940(03)00516-0 |
| Citation | Grass S, et al. (2003) Flexor reflex excitability in mice lacking galanin receptor galanin-R1. Neurosci Lett 345(3):153-6 |
| abstractText | This study was conducted to examine the excitability of the nociceptive flexor reflex and its sensitization by repetitive stimulation of C-fibers in anesthetized mice that lack the galanin-R1 receptor. Repetitive stimulation of C-fibers induced a gradual increase in reflex magnitude during the stimulation (wind-up), and a subsequent increase in spinal reflex excitability (central sensitization). This occurred in GAL-R1 -/-, GAL-R1 +/-, and +/+ wild-type controls, with no significant differences observed between genotypes. Intrathecal administration of galanin markedly blocked the sensitization following the repetitive stimulation in all three groups. No differences between wild-type or galanin-R1 receptor knockout mice were seen. These results confirm previous studies in rats, showing that intrathecal galanin reduces the central sensitization following wind-up. The present data indicate that this effect is probably mediated by receptors other than GAL-R1. |
