| Primary Identifier | MGI:2446889 | Allele Type | QTL |
| Gene | Gct1 | Inheritance Mode | Dominant |
| Strain of Origin | SWR/Bm | Is Recombinase | false |
| Is Wild Type | false |
| description | Granulosa cell tumor susceptibility (Gct) controls granulosa cell carcinoma formation in response to dehydroepiandrosterone (DHEA) treatment. Spontaneous ovarian granulosa cell (GC) carcinomas occur in the inbred strain SWR/Bm and in three SWXJ recombinant inbred strains. Dehydroepiandrosterone (DHEA) treatment of the SWXJ recombinant inbred (RI) strains and of the progenitor strains SWR/Bm and SJL/Bm caused an increase in GC tumor incidence in SWR and in the RI strains that produced tumors spontaneously, and also caused tumors in five RI strains that had not previously produced GC tumors. The other SWXJ strains and the SJL/Bm progenitor strain did not produce tumors (J:9301). |
| molecularNote | This allele confers susceptibility to granulosa cell tumor formation compared to SJL. |
