| First Author | Baliram R | Year | 2012 |
| Journal | J Clin Invest | Volume | 122 |
| Issue | 10 | Pages | 3737-41 |
| PubMed ID | 22996689 | Mgi Jnum | J:192466 |
| Mgi Id | MGI:5465222 | Doi | 10.1172/JCI63948 |
| Citation | Baliram R, et al. (2012) Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling. J Clin Invest 122(10):3737-41 |
| abstractText | The osteoporosis associated with human hyperthyroidism has traditionally been attributed to elevated thyroid hormone levels. There is evidence, however, that thyroid-stimulating hormone (TSH), which is low in most hyperthyroid states, directly affects the skeleton. Importantly, Tshr-knockout mice are osteopenic. In order to determine whether low TSH levels contribute to bone loss in hyperthyroidism, we compared the skeletal phenotypes of wild-type and Tshr-knockout mice that were rendered hyperthyroid. We found that hyperthyroid mice lacking TSHR had greater bone loss and resorption than hyperthyroid wild-type mice, thereby demonstrating that the absence of TSH signaling contributes to bone loss. Further, we identified a TSH-like factor that may confer osteoprotection. These studies suggest that therapeutic suppression of TSH to very low levels may contribute to bone loss in people. |
