| Primary Identifier | MGI:2447146 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Thy1-APP)3Somm |
| Strain of Origin | (C57BL/6J x DBA/2)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | The transgene was determined to be 7-fold over-expressed. |
| molecularNote | A mouse Thy1 promoter and a human APP751 cDNA sequence carrying the Swedish double mutation K670N and M671L found in Alzheimer's disease patients was used for the transgene. In situ hybridization analysis of brain sections from transgenic animals showed the highest levels of transgene expression in the neocortex and hippocampus. |
