| First Author | Van Dijck A | Year | 2008 |
| Journal | Behav Brain Res | Volume | 190 |
| Issue | 1 | Pages | 147-51 |
| PubMed ID | 18359101 | Mgi Jnum | J:133890 |
| Mgi Id | MGI:3784620 | Doi | 10.1016/j.bbr.2008.02.014 |
| Citation | Van Dijck A, et al. (2008) Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory. Behav Brain Res 190(1):147-51 |
| abstractText | The APP23 model is a transgenic mouse model for Alzheimer's disease. Cognitive performance in the APP23-model was assessed by Morris Water Maze (MWM) and passive avoidance learning, but the latter failed to show any difference between the genotypes. In search of a non-spatial alternative for assessment of hippocampus-dependent memory, we evaluated an odour paired-associate test, which is based on learning an association between two sets of odours. The protocol includes a shaping phase, in which the animals learn to dig up a reward, a preliminary training phase and a training phase, where the actual association is learned. Subsequently, mice are tested for transitive inference and subjected to a symmetry test. Impairment was seen in the APP23 mice, in comparison with wild type mice, in training; however, both groups failed the transitivity and symmetry test. Possible explanations for this discrepancy with earlier published results are the advanced age of the mice or the C57Bl/6J background, in which the model was established. |
