| First Author | Adams JM | Year | 1985 |
| Journal | Nature | Volume | 318 |
| Issue | 6046 | Pages | 533-8 |
| PubMed ID | 3906410 | Mgi Jnum | J:78177 |
| Mgi Id | MGI:2183676 | Doi | 10.1038/318533a0 |
| Citation | Adams JM, et al. (1985) The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318(6046):533-8 |
| abstractText | Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation. |
