| First Author | Lefebure M | Year | 2017 |
| Journal | Nat Commun | Volume | 8 |
| Pages | 14581 | PubMed ID | 28262675 |
| Mgi Jnum | J:244308 | Mgi Id | MGI:5913087 |
| Doi | 10.1038/ncomms14581 | Citation | Lefebure M, et al. (2017) Genomic characterisation of Emu-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene. Nat Commun 8:14581 |
| abstractText | The Emu-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Emu-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of Emu-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis. |
