| First Author | Vora KA | Year | 2001 |
| Journal | J Immunol | Volume | 166 |
| Issue | 5 | Pages | 3226-30 |
| PubMed ID | 11207276 | Mgi Jnum | J:67604 |
| Mgi Id | MGI:1930904 | Doi | 10.4049/jimmunol.166.5.3226 |
| Citation | Vora KA, et al. (2001) The t cell-dependent b cell immune response and germinal center reaction are intact in a-myb-deficient mice. J Immunol 166(5):3226-30 |
| abstractText | Expression of the protooncogene A-myb is restricted to the developing CNS, adult testes, breasts in late pregnancy, and germinal centers of secondary B cell follicles. The functional relevance of A-myb expression at three of these sites has been demonstrated previously via the generation and analysis of A-myb-deficient mice, which display behavioral abnormalities, male sterility, and perturbed breast development during pregnancy. In contrast, here we show that the germinal center response driven by T cell-dependent Ag immunization and the associated processes of Ab V gene somatic hypermutation, affinity maturation, and heavy chain class switching are overtly normal in A-myb-deficient mice. Nonetheless, these mice display mild splenic white pulp hypoplasia and blunted primary serum Ab responses, suggesting that although A-myb is not directly involved in the regulation of the memory B cell response, it may play a role in enhancing peripheral B cell survival or proliferative capacity. |
