| First Author | Zong Y | Year | 2015 |
| Journal | Brain Res | Volume | 1624 |
| Pages | 95-102 | PubMed ID | 26212654 |
| Mgi Jnum | J:316467 | Mgi Id | MGI:6837786 |
| Doi | 10.1016/j.brainres.2015.07.022 | Citation | Zong Y, et al. (2015) miR-29c regulates NAV3 protein expression in a transgenic mouse model of Alzheimer's disease. Brain Res 1624:95-102 |
| abstractText | The microRNA-29 family (miRNA-29s) has three mature members, miR-29a, miR-29b and miR-29c, which have been implicated in the regulation of the pathogenesis of Alzheimer's disease (AD). The miR-29 family members exhibit differential regulation in various diseases and different subcellular distribution. In the present study, we initially investigated differential expression of miR-29c in the hippocampus and the frontal cortex of the young APPswe/PSDeltaE9 mouse brain, accompanied by inverse expression of neurone navigator 3 (NAV3), a regulator of axon guidance. We observed that miR-29c directly mediated downregulation of NAV3 protein expression in vitro. The mouse NAV3 mRNA has a functional miR-29c binding site in the 3' UTR, which localized in the position between 830-836 bp of 3'UTR region, slightly different from human NAV3 mRNA binding site. These observations suggest that miR-29c may be involved in neurodegenerative processes by regulating NAV3 expression in the young AD mouse. |
