| First Author | Ueno K | Year | 2008 |
| Journal | Am J Respir Cell Mol Biol | Volume | 38 |
| Issue | 3 | Pages | 263-8 |
| PubMed ID | 18079492 | Mgi Jnum | J:146352 |
| Mgi Id | MGI:3837298 | Doi | 10.1165/rcmb.2007-0336RC |
| Citation | Ueno K, et al. (2008) MUC1 mucin is a negative regulator of toll-like receptor signaling. Am J Respir Cell Mol Biol 38(3):263-8 |
| abstractText | MUC1 (MUC1 in humans and Muc1 in nonhuman species) is a transmembrane mucin-like glycoprotein expressed in epithelial cells lining various mucosal surfaces as well as hematopoietic cells. Recently, we showed that Muc1(-/-) mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, and our studies with cultured cells revealed that MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting its anti-inflammatory role. Here we demonstrate that other TLR signaling (TLR2, 3, 4, 7, and 9) is also suppressed by MUC1/Muc1. The results from this study suggest that MUC1/Muc1 may play a crucial role during airway infection and inflammation by various pathogenic bacteria and viruses. |
