| Primary Identifier | MGI:2447846 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Pcp2-SCA7)P7EJman |
| Strain of Origin | C57BL/6 x SJL | Is Recombinase | false |
| Is Wild Type | false |
| description | Transgenic lines B, C, and E were constructed. Line B carries 10-50 copies of the integrated transgene and expresses the highest amount of transgene product. |
| molecularNote | The transgene consists of a Pcp2 promoter, the full-length mutant human Sca7 gene carrying a 90 glutamine repeat expansion, and an SV40 intron and polyadenylation sequence. Pcp2 promoter sequences target transgene expression to Purkinje cells. Transgene expression was observed in Purkinje cells by immunofluorescence. |
