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Allele : Gclm<tm1Tdal> glutamate-cysteine ligase, modifier subunit; targeted mutation 1, Timothy P Dalton

Primary Identifier  MGI:2447852 Allele Type  Targeted
Attribute String  Null/knockout Gene  Gclm
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
description  ES cell line = J1 (129S4/SvJae) or D, which is E14TG2a (129P2/OlaHsd).
molecularNote  Exon 1 was disrupted by the insertion of a neomycin selection cassette. The 3' splice donor site of intron 1 was deleted and translation from either of the putative start codons is expected to terminate after 61 residues. Neither normal transcript nor normal protein was detected by Northern and Western blot analyses of liver and kidney tissue obtained from homozygous mutant mice.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • Gclm(-),
  • GCLM<->,
  • Gclm(-),
  • GCLM<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

30 Publication categories