| First Author | Ehrenstein MR | Year | 2000 |
| Journal | J Exp Med | Volume | 191 |
| Issue | 7 | Pages | 1253-8 |
| PubMed ID | 10748243 | Mgi Jnum | J:111817 |
| Mgi Id | MGI:3654883 | Doi | 10.1084/jem.191.7.1253 |
| Citation | Ehrenstein MR, et al. (2000) Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies. J Exp Med 191(7):1253-8 |
| abstractText | Serum immunoglobulin (Ig)M provides the initial response to foreign antigen and plays a regulatory role in subsequent immune response development, accelerating the production of high-affinity IgG. Here we show that mice deficient in serum IgM have an increased propensity to spontaneous autoimmunity as judged by the development with age of serum IgG anti-DNA antibodies and the renal deposition of IgG and complement. They also exhibit augmented anti-DNA IgG production on exposure to lipopolysaccharide. Thus, deficiency in serum IgM leads to diminished responsiveness to foreign antigens but increased responsiveness to self-a paradoxical association reminiscent of that described in humans deficient in complement or IgA.We wondered whether serum IgM might play an analogous role with regard to the response to self-antigens. However, here-in contrast to the sluggish response to foreign antigens-we find that deficiency in serum IgM actually predisposes to the development of IgG antibodies to autoantigens. |
