| First Author | Baker N | Year | 2002 |
| Journal | J Immunol | Volume | 169 |
| Issue | 12 | Pages | 6686-90 |
| PubMed ID | 12471099 | Mgi Jnum | J:80656 |
| Mgi Id | MGI:2446748 | Doi | 10.4049/jimmunol.169.12.6686 |
| Citation | Baker N, et al. (2002) Cutting Edge: Selection of B Lymphocyte Subsets Is Regulated by Natural IgM. J Immunol 169(12):6686-90 |
| abstractText | Natural IgM has a wide range of actions in the immune system. Here we demonstrate that mice lacking serum IgM have an expansion in splenic marginal zone B cells with a proportionately smaller reduction in follicular B cells. The increase in the marginal zone-follicular B cell ratio (and an expansion in peritoneal B1a cells) is fully reversed by administration of polyclonal IgM, but not by two IgM monoclonals. Mice engineered to have a secreted oligoclonal IgM repertoire with an endogenous membrane IgM also exhibited a similar expansion of marginal zone B cells. We propose that natural IgM, by virtue of its polyreactivity, enhances Ag-driven signaling through the B cell receptor and promotes the formation of follicular B cells. These results demonstrate that natural IgM regulates the selection of B lymphocyte subsets. |
