| First Author | Verbeek S | Year | 1991 |
| Journal | Mol Cell Biol | Volume | 11 |
| Issue | 2 | Pages | 1176-9 |
| PubMed ID | 1990273 | Mgi Jnum | J:71550 |
| Mgi Id | MGI:2150295 | Doi | 10.1128/mcb.11.2.1176 |
| Citation | Verbeek S, et al. (1991) Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally. Mol Cell Biol 11(2):1176-9 |
| abstractText | Previously, it has been shown that E mu-pim-1 transgenic mice are predisposed to T-cell lymphomas, whereas E mu-myc transgenic mice are predisposed to pre-B-cell lymphomas. Here we show that double-transgenic E mu-myc E mu-pim-1 mice exhibit pre-B-cell leukemia in utero. Upon transplantation into recipient mice, embryo-derived double-transgenic leukemic cells frequently progressed to highly malignant monoclonal tumors, indicating that additional (epi)genetic events had occurred during the progression of the disease. |
