| First Author | Lee S | Year | 2008 |
| Journal | Dev Cell | Volume | 14 |
| Issue | 6 | Pages | 877-89 |
| PubMed ID | 18539116 | Mgi Jnum | J:328860 |
| Mgi Id | MGI:7339313 | Doi | 10.1016/j.devcel.2008.03.021 |
| Citation | Lee S, et al. (2008) A regulatory network to segregate the identity of neuronal subtypes. Dev Cell 14(6):877-89 |
| abstractText | Spinal motor neurons (MNs) and V2 interneurons (V2-INs) are specified by two related LIM-complexes, MN-hexamer and V2-tetramer, respectively. Here we show how multiple parallel and complementary feedback loops are integrated to assign these two cell fates accurately. While MN-hexamer response elements (REs) are specific to MN-hexamer, V2-tetramer-REs can bind both LIM-complexes. In embryonic MNs, however, two factors cooperatively suppress the aberrant activation of V2-tetramer-REs. First, LMO4 blocks V2-tetramer assembly. Second, MN-hexamer induces a repressor, Hb9, which binds V2-tetramer-REs and suppresses their activation. V2-INs use a similar approach; V2-tetramer induces a repressor, Chx10, which binds MN-hexamer-REs and blocks their activation. Thus, our study uncovers a regulatory network to segregate related cell fates, which involves reciprocal feedforward gene regulatory loops. |
