| First Author | Poirier C | Year | 2004 |
| Journal | Genetics | Volume | 168 |
| Issue | 3 | Pages | 1557-62 |
| PubMed ID | 15579706 | Mgi Jnum | J:94131 |
| Mgi Id | MGI:3511370 | Doi | 10.1534/genetics.104.032177 |
| Citation | Poirier C, et al. (2004) A complex interaction of imprinted and maternal-effect genes modifies sex determination in odd sex (ods) mice. Genetics 168(3):1557-62 |
| abstractText | The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods termed Odsm1(A). Here we show that phenotypic sex depends on a complex interaction between the suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo. |
