| Primary Identifier | MGI:2448655 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence, Modified isoform(s) | Gene | Tg(Pbsn-FGFR2_iiib*)#Ng |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| description | Three transgenic lines (3260, 3425, and 5806) were created. The prostates of transgenic animals are visibly smaller compared to wild-type. |
| molecularNote | The transgene consists of a rat Pbsn minimal promoter and a dominant negative human FGFR2 (isoform iiib) cDNA. The rat probasin minimal promoter (-426 to +28) was used to drive transgene expression in prostate epithelium. Three lines were established: 3260, 3425, 5806, however, the pound symbol (#) is used when lines are pooled. |
