| First Author | Lagasse E | Year | 1994 |
| Journal | J Exp Med | Volume | 179 |
| Issue | 3 | Pages | 1047-52 |
| PubMed ID | 8113673 | Mgi Jnum | J:81148 |
| Mgi Id | MGI:2448128 | Doi | 10.1084/jem.179.3.1047 |
| Citation | Lagasse E, et al. (1994) bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med 179(3):1047-52 |
| abstractText | Neutrophils, the most common inflammatory leukocytes, have the most limited life span of all blood cells. After they undergo apoptosis, they are recognized and engulfed by macrophages. bcl-2, a proto-oncogene rearranged and deregulated in B cell lymphomas bearing the t(14;18) translocation, is known to inhibit programmed death. bcl-2 expression is localized in early myeloid cells of the bone marrow but is absent in mature neutrophils. Transgenic mice that expressed bcl-2 in mature neutrophils showed that bcl-2 blocked neutrophil apoptosis. Despite this, homeostasis of neutrophil population is essentially unaffected. In fact, macrophage uptake of neutrophils expressing bcl-2 still occurred. This transgenic model indicates that the mechanism that triggers phagocytosis of aging neutrophils operates independently of the process of apoptosis regulated by bcl-2. |
