| First Author | Nakamichi Y | Year | 2003 |
| Journal | Mol Cell Biol | Volume | 23 |
| Issue | 2 | Pages | 636-44 |
| PubMed ID | 12509461 | Mgi Jnum | J:81137 |
| Mgi Id | MGI:2448115 | Doi | 10.1128/MCB.23.2.636-644.2003 |
| Citation | Nakamichi Y, et al. (2003) Chondromodulin I is a bone remodeling factor. Mol Cell Biol 23(2):636-44 |
| abstractText | Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I(-/-) mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I(-/-) mice. Thus, the present study established that ChM-I is a bone remodeling factor. |
