| First Author | Mack DL | Year | 2002 |
| Journal | Immunology | Volume | 107 |
| Issue | 4 | Pages | 444-51 |
| PubMed ID | 12460189 | Mgi Jnum | J:80777 |
| Mgi Id | MGI:2447119 | Doi | 10.1046/j.1365-2567.2002.01523.x |
| Citation | Mack DL, et al. (2002) Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development. Immunology 107(4):444-51 |
| abstractText | The haematopoietic homeobox gene Hex (also called Prh) is expressed in myeloid cells and B cells but not T cells. To investigate whether Hex levels might play a role in myeloid versus T-cell development, two types of transgenic mouse lines were constructed, each with ectopic expression of Hex in T cells (CD11a/Hex and Lck/Hex). Both these types of transgenic mouse had the same defects in T-cell maturation, indicating that proper T-cell development may be dependent not just on the up-regulation of lymphoid-specific transcriptional regulators but also on the co-ordinated down-regulation of myeloid-specific transcriptional regulators such as Hex. In addition, Hex over-expression significantly increased myeloid progenitor cycling, which may explain its role in retrovirally induced murine leukaemia. |
