| First Author | Lacronique V | Year | 1996 |
| Journal | Nat Med | Volume | 2 |
| Issue | 1 | Pages | 80-6 |
| PubMed ID | 8564847 | Mgi Jnum | J:81129 |
| Mgi Id | MGI:2448107 | Doi | 10.1038/nm0196-80 |
| Citation | Lacronique V, et al. (1996) Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med 2(1):80-6 |
| abstractText | Fas is an apoptosis-signalling cell surface antigen that has been shown to trigger cell death upon specific ligand or antibody binding. Treatment of mice with an anti-Fas antibody causes fulminant hepatic failure due to massive apoptosis. To test a putative protective effect of the anti-apoptotic Bcl-2 protein, transgenic mice were generated to express the human bcl-2 gene product in hepatocytes. Early onset of massive hepatic apoptosis leading to death was observed in all nontransgenic mice treated with an anti-Fas antibody. By contrast, hepatic apoptosis was delayed and dramatically reduced in transgenic animals, yielding a 93% survival rate. These results demonstrate that Bcl-2 is able to protect from in vivo Fas-mediated cytotoxicity, and could be of significance for preventing fulminant hepatic failure due to viral hepatitis in humans. |
