| First Author | Mayer CE | Year | 2016 |
| Journal | Eur J Immunol | Volume | 46 |
| Issue | 4 | Pages | 846-56 |
| PubMed ID | 26694097 | Mgi Jnum | J:268680 |
| Mgi Id | MGI:5924143 | Doi | 10.1002/eji.201545995 |
| Citation | Mayer CE, et al. (2016) Dynamic spatio-temporal contribution of single beta5t+ cortical epithelial precursors to the thymus medulla. Eur J Immunol 46(4):846-56 |
| abstractText | Intrathymic T-cell development is critically dependent on cortical and medullary thymic epithelial cells (TECs). Both epithelial subsets originate during early thymus organogenesis from progenitor cells that express the thymoproteasome subunit beta5t, a typical feature of cortical TECs. Using in vivo lineage fate mapping, we demonstrate in mice that beta5t(+) TEC progenitors give rise to the medullary TEC compartment early in life but significantly limit their contribution once the medulla has completely formed. Lineage-tracing studies at single cell resolution demonstrate for young mice that the postnatal medulla is expanded from individual beta5t(+) cortical progenitors located at the cortico-medullary junction. These results therefore not only define a developmental window during which the expansion of medulla is efficiently enabled by progenitors resident in the thymic cortex, but also reveal the spatio-temporal dynamics that control the growth of the thymic medulla. |
