| First Author | Ohigashi I | Year | 2015 |
| Journal | Cell Rep | Volume | 13 |
| Issue | 7 | Pages | 1432-1443 |
| PubMed ID | 26549457 | Mgi Jnum | J:228959 |
| Mgi Id | MGI:5749898 | Doi | 10.1016/j.celrep.2015.10.012 |
| Citation | Ohigashi I, et al. (2015) Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors. Cell Rep 13(7):1432-43 |
| abstractText | Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also have been reported. Here, we report in vivo fate-mapping analysis of cells that transcribe beta5t, a cTEC trait expressed in bipotent progenitors, during a given period in mice. We show that, in adult mice, most mTECs are derived from progenitors that transcribe beta5t during embryogenesis and the neonatal period up to 1 week of age. The contribution of adult beta5t(+) progenitors was minor even during injury-triggered regeneration. Our results further demonstrate that adult mTEC-restricted progenitors are derived from perinatal beta5t(+) progenitors. These results indicate that the adult thymic medullary epithelium is maintained and regenerated by mTEC-lineage cells that pass beyond the bipotent stage during early ontogeny. |
