| First Author | Kassiotis G | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 3 | Pages | 244-50 |
| PubMed ID | 11836529 | Mgi Jnum | J:151747 |
| Mgi Id | MGI:4355136 | Doi | 10.1038/ni766 |
| Citation | Kassiotis G, et al. (2002) Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol 3(3):244-50 |
| abstractText | The mechanisms by which immunological memory is maintained after infection or vaccination are still a matter of debate. Long-term survival of memory T cells does not require major histocompatibility complex (MHC) contact. We show here that compared with memory CD4+ T cells that maintain contact with MHC class II, memory CD4+ T cells deprived of MHC class II contact show distinct functional defects upon antigen re-encounter. Thus, in contrast to their survival, maintenance of the typical quality of memory T cells crucially depends on MHC-derived signals. |
