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Allele : Syn1<tm1Pggd> synapsin I; targeted mutation 1, Paul Greengard

Primary Identifier	MGI:2448356	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Syn1
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

Exon 1 was replaced by a neomycin selection cassette inserted by homologous recombination. Western blot analysis of homozygous mutant brain tissues indicated an absence of both protein isoforms, Synapsin Ia and Synapsin Ib, produced by the endogenous locus.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
SynI<->,
Syn1<tm1Lli>,
Syn1<tm1Lli>,
SynI<->

earliestPublication:
Chin LS, et al. (1995) Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. Proc Natl Acad Sci U S A 92(20):9230-4

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

3 Carried By

0 Driven By

52 Publication categories

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