| First Author | Stavsky A | Year | 2024 |
| Journal | Elife | Volume | 12 |
| PubMed ID | 38713200 | Mgi Jnum | J:359062 |
| Mgi Id | MGI:7782744 | Doi | 10.7554/eLife.89687 |
| Citation | Stavsky A, et al. (2024) Synapsin E-domain is essential for alpha-synuclein function. Elife 12 |
| abstractText | The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here, we identify the synapsin E-domain as an essential functional binding-partner of alpha-synuclein (alpha-syn). Synapsin E-domain allows alpha-syn functionality, binds to alpha-syn, and is necessary and sufficient for enabling effects of alpha-syn at synapses of cultured mouse hippocampal neurons. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters. |
