| First Author | Bartke A | Year | 2003 |
| Journal | Neuroendocrinology | Volume | 78 |
| Issue | 4 | Pages | 210-6 |
| PubMed ID | 14583653 | Mgi Jnum | J:86298 |
| Mgi Id | MGI:2679361 | Doi | 10.1159/000073704 |
| Citation | Bartke A (2003) Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology 78(4):210-6 |
| abstractText | Overexpression of heterologous growth hormone (GH) in transgenic mice results in numerous phenotypic effects, including a drastically shortened life span. Early onset of pathological changes in the kidneys, glomerulosclerosis and glomerulonephritis, undoubtedly contributes to and perhaps accounts for reduced longevity of these animals. However, GH-transgenic mice exhibit various symptoms of accelerated aging, including increased astrogliosis, shortened reproductive life span, and early onset of age-related changes in cognitive function, hypothalamic neurotransmitter turnover, and plasma corticosterone levels. The hypothesis that supraphysiological levels of GH can accelerate aging derives indirect support from findings in GH-deficient and GH-resistant mutant mice in which aging is delayed and the life-span is increased and from the reciprocal relationship of body size and longevity within species. |
