| First Author | Shelton CD | Year | 2023 |
| Journal | Cell Host Microbe | Volume | 31 |
| Issue | 10 | Pages | 1604-1619.e10 |
| PubMed ID | 37794592 | Mgi Jnum | J:351841 |
| Mgi Id | MGI:7542795 | Doi | 10.1016/j.chom.2023.09.002 |
| Citation | Shelton CD, et al. (2023) An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism. Cell Host Microbe 31(10):1604-1619.e10 |
| abstractText | The mechanisms by which the early-life microbiota protects against environmental factors that promote childhood obesity remain largely unknown. Using a mouse model in which young mice are simultaneously exposed to antibiotics and a high-fat (HF) diet, we show that Lactobacillus species, predominant members of the small intestine (SI) microbiota, regulate intestinal epithelial cells (IECs) to limit diet-induced obesity during early life. A Lactobacillus-derived metabolite, phenyllactic acid (PLA), protects against metabolic dysfunction caused by early-life exposure to antibiotics and a HF diet by increasing the abundance of peroxisome proliferator-activated receptor gamma (PPAR-gamma) in SI IECs. Therefore, PLA is a microbiota-derived metabolite that activates protective pathways in the small intestinal epithelium to regulate intestinal lipid metabolism and prevent antibiotic-associated obesity during early life. |
