| First Author | Oudhoff MJ | Year | 2013 |
| Journal | Dev Cell | Volume | 26 |
| Issue | 2 | Pages | 188-94 |
| PubMed ID | 23850191 | Mgi Jnum | J:199305 |
| Mgi Id | MGI:5502255 | Doi | 10.1016/j.devcel.2013.05.025 |
| Citation | Oudhoff MJ, et al. (2013) Control of the hippo pathway by set7-dependent methylation of yap. Dev Cell 26(2):188-94 |
| abstractText | Methylation of nonhistone proteins is emerging as a regulatory mechanism to control protein function. Set7 (Setd7) is a SET-domain-containing lysine methyltransferase that methylates and alters function of a variety of proteins in vitro, but the in vivo relevance has not been established. We found that Set7 is a modifier of the Hippo pathway. Mice that lack Set7 have a larger progenitor compartment in the intestine, coinciding with increased expression of Yes-associated protein (Yap) target genes. Mechanistically, monomethylation of lysine 494 of Yap is critical for cytoplasmic retention. These results identify a methylation-dependent checkpoint in the Hippo pathway. |
