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Allele : Tg(ACTFLPe)9205Dym transgene insertion 9205, Susan Dymecki
Primary Identifier  MGI:2448985 Allele Type  Transgenic
Attribute String  Recombinase Gene  Tg(ACTFLPe)9205Dym
Strain of Origin  (C57BL/6 x SJL)F2 Is Recombinase  true
Is Wild Type  false
description  The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37°C and 40°C, respectively. Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
molecularNote  Sequence encoding FLP1 was adjoined to human ACTB promoter sequence, including 3 kb of promoter sequence and an 0.8 kb portion of exon 1. The promoter region drives expression in the germline. Recombinase activity is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5.
  • mutations:
  • Insertion
  • synonyms:
  • hACTB::FLPe,
  • TgaFlpe,
  • Tg(ACTB-FlpE)9205Dym,
  • ACTB-Flpe,
  • hACTB::FLPe,
  • ACTB::FLPe,
  • hACTB-FLPe,
  • Flp deleter,
  • CAGGS-flp,
  • FLPe,
  • Flp,
  • FLPe,
  • ACT-FLPe,
  • ACTB::FLPe,
  • ACTB-Flpe,
  • ACTFlpe,
  • ACT-FLPe,
  • beta-actinFLPe,
  • Tg(ACTB-flpe)9205Dym,
  • ACTB:FLPe,
  • Flp deleter,
  • Tg (ACTFLEe)9205Dym,
  • Flp,
  • TgaFlpe,
  • hACTB-FLPe,
  • CAGG-Flpr,
  • CAGGS-flp,
  • ACTFlpe,
  • Tg(ACTB-FlpE)9205Dym,
  • actin-FLPe,
  • TgpCAG-flpe,
  • TgpCAG-flpe,
  • Tg (ACTFLEe)9205Dym,
  • actin-FLPe,
  • Tg(ACTB-flpe)9205Dym,
  • CAGG-Flpr,
  • ACTB:FLPe,
  • beta-actinFLPe
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

5 Carried By

1 Driven By

1073 Publication categories





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