| First Author | Oshiro H | Year | 2015 |
| Journal | Genes Cells | Volume | 20 |
| Issue | 2 | Pages | 108-20 |
| PubMed ID | 25441120 | Mgi Jnum | J:230288 |
| Mgi Id | MGI:5755924 | Doi | 10.1111/gtc.12205 |
| Citation | Oshiro H, et al. (2015) Up-regulation of HP1gamma expression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex. Genes Cells 20(2):108-20 |
| abstractText | Immature neurons undergo morphological and physiological changes including axonal and dendritic development to establish neuronal networks. As the transcriptional status changes at a large number of genes during neuronal maturation, global changes in chromatin modifiers may take place in this process. We now show that the amount of heterochromatin protein 1gamma (HP1gamma) increases during neuronal maturation in the mouse neocortex. Knockdown of HP1gamma suppressed axonal and dendritic development in mouse embryonic neocortical neurons in culture, and either knockdown or knockout of HP1gamma impaired the projection of callosal axons of superficial layer neurons to the contralateral hemisphere in the developing neocortex. Conversely, forced expression of HP1gamma facilitated axonal and dendritic development, suggesting that the increase of HP1gamma is a rate limiting step in neuronal maturation. These results together show an important role for HP1gamma in promoting axonal and dendritic development in maturing neurons. |
